is alcohol abuse which leads to fatty liver disease which is very prevalent in the Eastern and North-eastern region. Heavy alcohol consumption causes alcoholic liver disease, while tobacco use increases the risk of liver cancer. The rural settings also bring several infections that can be transmitted through contaminated food, water, and blood products - all of which can lead to chronic liver inflammation and damage over time, needing liver transplants. Dr Raj Vigna Venugopal says that in Eastern/North Eastern India, many patients suffer from gallbladder and pancreatic disease, with gallbladder and bile duct stones being the most common. Tropical pancreatitis, a condition where stones form in the pancreas, is also prevalent in the region, and its treatment requires a multidisciplinary approach, which their team is well-equipped to provide. Pancreatic diseases are a significant cause of liver problems, as the liver plays a critical role in processing nutrients and filtering toxins from the digestive tract. Therefore, it's crucial to investigate patients with persistent symptoms to diagnose the underlying cause and provide timely treatment of stones. Failure to do so may lead to severe complications like jaundice and sepsis. With this in mind, Manipal Hospital Old Airport Road recently organized a press conference in Kolkata on 18th April to address the alarming rise of liver diseases in the Eastern/ North East region of India. The conference featured Dr Rajiv Lochan, Lead Consultant - HPB and Liver Transplantation Surgery, Manipal Hospital Old Airport Road, and Dr Raj Vigna Venugopal, HOD & Consultant – Medical Gastroenterology, Manipal Hospital Old Airport Road. The conference ended with a reminder of the importance of organ donation to increase the number of transplants and save lives. Transplantation is a highly successful treatment for liver disease. Brain-dead donations must increase to meet the demand for liver transplants. Living liver donation is a safe option for healthy individuals to donate a part of their liver to those in need. Healthy people should consider living liver donation as a safe and effective approach to aid those in need of a transplant.